Von Willebrand Disease ‘Type 3’ (Bleeding Disorder)

Von Willebrand disease is a common, lifelong bleeding disorder which results from a deficiency or abnormality of a multi-adhesive protein called 'Von Willebrand factor' (VWF) which helps the blood to clot.

The VWF protein is responsible for binding together the platelets, which are the tiny cells that circulate in the blood to plug broken blood vessels and stop bleeding. Low levels of functional VWF in people suffering from Von Willebrand disease affect the clotting ability of the platelets, thereby leading to prolonged bleeding.

Von Willebrand disease is generally considered an inherited bleeding disorder, but it can also sometimes develop later in life. The disease affects both men and women at the same rate.

‘Type 3’ Von Willebrand disease is rare, but the most severe, form of the bleeding disorder.

In the most common 'Type 1' of the disease, the level of platelets in the blood is lower than normal; while in 'Type 2' of the disease, the levels of VWF are normal, but it cannot work properly due to structural or functional defects. However, in Type 3 Von Willebrand disease, the body produces very little or no VWF, and potentially puts an individual at the risk of heavy bleeding which can be so severe that it may include joint, muscle or gastrointestinal bleeding.

Von Willebrand disease can lead to several health complications, such as Anaemia (iron deficiency in the body), pain and swelling, and even death from uncontrolled bleeding. The risk of complications resulting can be higher for women than in men, because of a higher chance of bleeding during menstruation, pregnancy, and childbirth.

WHAT ARE THE CAUSES OF VON WILLEBRAND DISEASE

The main cause behind the occurrence of Von Willebrand disease is a genetic mutation, which is inherited by an affected individual from one or both parents. The inherited faulty gene causes problems with the VWF protein which plays a key role in the blood-clotting process.

People who have inherited only one copy of the mutated gene usually develop Type 1 or Type 2 Von Willebrand disease, but people who inherit a mutated gene from both parents suffer from Type 3 Von Willebrand disease.

WHAT ARE THE SYMPTOMS OF VON WILLEBRAND DISEASE

The symptoms of Von Willebrand disease may be mild or severe and may start at any age. The symptoms generally depend on the type of Von Willebrand disease a person may be suffering from. However, some of the symptoms common to all the three types of the disease are:

• Easy bruising
• Getting large and lumpy bruises
• Excessive and long-lasting nosebleeds
• Bleeding from the gums
• Heavy or prolonged bleeding after tooth removal or surgery
• Abnormally heavy bleeding during menstruation (in women)
• Blood in urine due to bleeding in the kidneys or bladder
• Blood in stool (feces) due to bleeding in intestines or stomach.

VON WILLEBRAND DISEASE: AYURVEDIC VIEWPOINT

According to Ayurveda, blood tissue is one of the seven tissues (Dhatu) of the body. Since blood (Rakta) is associated with the body’s Pitta dosha, bleeding disorders like Von Willebrand disease mostly occur due to a Pitta imbalance.

In Ayurveda, a collective term used for all bleeding disorders is ‘Raktapitta.’ Ayurvedic experts believe that bleeding disorders are usually caused by excessive intake of warm (ushna), penetrative (teekshna), salty (lavana), sour (amla), and spicy (vidahi) foods, as well as other foods or drinks which can aggravate Pitta dosha. Moreover, in some cases, excessive exposure to the sun, or working n the sun for long periods, can also cause bleeding disorders.

VON WILLEBRAND DISEASE: TREATMENT

The treatment of Von Willebrand disease is chiefly focused on stopping or preventing bleeding episodes, particularly with the help of medications which enable the formation of blood clots by platelets.

Though the treatment plan for patients suffering from Von Willebrand disease usually varies in accordance with the type of condition they have, some of the treatment options for the disease include drug therapies, nonreplacement therapy, replacement therapy, and topical treatments.

Herbal Remedies For Von Willebrand Disease

For managing Von Willebrand disease in a safe and natural manner, some excellent herbal products are available from Planet Ayurveda herbal manufacturing company. These products, prepared from 100% pure herbs, are:

1. Pitta Balance Capsules

The preparation of these capsules involves the use of some beneficial herbal components, including Praval Pishti (Coral Calcium), Mukta Pishti (Pearl Calcium), Akik Pishti (Agate Calcium), Jawar Mohra Pishti (an Ayurvedic Calcium compound), Kamdhudha Ras (an Ayurvedic Calcium compound), and Giloy satva (extract of Tinospora cordifolia).

The use of these capsules is beneficial for the management of Von Willebrand disease because of the ability of herbal ingredients to purify the blood, treat bleeding disorders, control blood pressure, support the immune system, and balance the Pitta dosha.

DOSAGE: 2 capsules, two times a day with plain water after 30 mins of the meal.

2. Coolstrin-B Capsules

For preparing these capsules, a combination of potent herbs is used, including Nagkesar (Mesua fera), Lodhra (Symplocos racemosus), Mochrus (Salmalia Malabarica), Dhataki (Woodfordia fruiticosa), and Lajjalu (Mimosa pudica).

Patients suffering from Von Willebrand disease can benefit from the use of these capsules because of the ability of the herbal ingredients to manage bleeding disorders, treat pain and inflammation, heal the intestines, maintain pH of the body, boost the immune system, and pacify the Pitta dosha.

DOSAGE: 1 capsule, two times daily with plain water after 30 mins of the meal.

3. Chanderprabha Vati

A combination of several herbs and other beneficial natural ingredients is used for preparing these tablets, including Karpura (Cinnamomum camphora), Shilajit (Asphaltum), Guggulu (Commiphora mukul), Vacha (Acorus calamus), Mustak (Cyperus rotundus), Haritaki (Terminalia chebula), Vibhitaki (Terminalia bellirica), Amalaki (Emblica officinalis), Haridra (Curcuma longa), Pippali (Piper longum), Maricha (Piper nigrum), Danti (Baliospermum montanum), Chavya (Piper chaba), Vidanga (Embelia ribes), Shunti (Zingiber officinalis), Tejpatta (Cinnamomum tamala), Dalchini (Cinnamomum zeylanicum), Ela (Elettaria cardamomum), Yavkshaar (Potassium carbonate), Sarjikshaar (Sodium carbonate), Vida Lavana (Black salt), Saindhava Lavana (Rock salt), Sauvarchala Lavana (Sodium sulphate), and Sharkara (Sugar).

The use of these tablets can be helpful in managing Von Willebrand disease because their natural ingredients can purify the blood, eliminate toxins from the body, reduce pain and swelling, treat bleeding disorders, and manage bladder-related disorders.

DOSAGE: 2 tablets, two times a day with plain water after 30 mins of the meal.

4. Manjistha Capsules

Standardized extract of the 'Manjistha' herb (Rubia cordifolia) is used for the preparation of these capsules. The herb is widely used in Ayurvedic formulations because of its anti-inflammatory, anti-bacterial, anti-microbial, astringent, antispasmodic, blood-purifier, and immunity-enhancer properties.

These capsules have the ability to manage Von Willebrand disease because they can treat blood disorders, remove toxins from the body, treat skin diseases, keep the urinary system healthy, and balance the Pitta dosha.

DOSAGE: 2 capsules, two times a day with plain water after 30 mins of the meal.

5. Green Essentials

The preparation of these capsules involves the use of a number of herbs, including Amalaki (Emblica officinalis), Spirulina (Spirulina platensis), Green tea (Camellia sinensis), wheat grass (Triticulum aestivum), and grape seed (Vitis vinifera).

People suffering from Von Willebrand disease can benefit from the use of these capsules because they can manage blood disorders, boost the immune system, provide nourishment to the brain cells, and help the body fight against free radicals.

DOSAGE: 2 capsules, two times a day with plain water after 30 mins of the meal.

CONCLUSION

Planet Ayurveda's herbal products can be very beneficial in the managing Von Willebrand disease, because the products do not contain any chemicals, preservatives, additives, binders, artificial colours or fillers. Nonetheless, it is recommended that patients suffering from the disease should use these products after consulting an expert Ayurveda practitioner.

Contact my assistant to provide you the costing / ordering and delivery information at - costing.planetayurveda@gmail.com or call at +91-172-5214030

Ayurvedic Treatment of Coagulopathy - Symptoms, Causes, Diagnosis, Diet & Herbal Remedies

Coagulation disorders also called bleeding disorder, are disturbances in the body’s ability to control blood clotting. Coagulation disorders are either a hemorrhage (i.e. Too little clotting that will increase a risk of bleeding) or thrombosis or thrombophilia (too much clotting that will cause blood clots to block the blood flow).

The various proteins in the blood play an important role in a normal clotting process. Coagulopathy is caused by reducing levels of blood-clotting proteins, known as clotting factors or coagulation factors. There are some genetic disorders, like hemophilia and Von Willebrand’s disease, also can cause a reduction in coagulation factors. Coagulopathy may also occur due to reduced levels of platelets.

COMMON SYMPTOMS OF COAGULOPATHY

Experiencing coagulopathy symptoms daily or once a while, sometimes these can be severe. The following symptoms may occur:

• Abnormal menstrual bleeding
• Bleeding of the mouth and gums
• Easy bleeding or bruising
• Frequent nosebleeds

SYMPTOMS OF COAGULOPATHY FOLLOWING INJURY

Coagulopathy reduces the blood clotting ability. Some bleeding may be occurring after a minor surgery or injury, excessive bleeding is a symptom of coagulopathy. Excessive or extended bleeding may occur after:

• Dental procedures
• Loss of a tooth
• Minor cuts
• Surgery

SYMPTOMS OF COAGULOPATHY FOLLOWING JOINT BLEEDING

Excessive bleeding in an elbows, knees or other joints caused due to coagulopathy. There are some symptoms indicates that the bleeding is occurring in joints:

• Joint pain
• Joint swelling
• The Joint feels hot to the touch
• Joint tightness
• Reduced mobility

SYMPTOMS OF COAGULOPATHY INDICATE A LIFE-THREATENING CONDITION

In some conditions, coagulopathy can cause bleeding in the person's brain or internal organs, which can be life threatening. Some life-threatening symptoms include:

• Pink-colored urine (hematuria)
• Bloody stool
• Loss of consciousness
• Seizures
• Loss of vision or changes in vision
• Repeated vomiting

CAUSES OF COAGULOPATHY

Healthy platelet level requires for Blood clotting and there are 20 proteins involved, called clotting factors, or coagulation factors. When the body lacks or has low levels of one or more of these proteins, then it causes coagulopathy. Coagulopathy also occurs when the level of platelets reduced.

GENETIC CAUSES OF COAGULOPATHY

There is some genetic disorder which causes coagulopathy, such as:

• Antithrombin III deficiency
• Factor II deficiency
• Factor V deficiency
• Factor VII deficiency
• Factor X deficiency
• Factor XII deficiency
• Protein C deficiency
• Protein S deficiency
• Hemophilia A or B
• Von Willebrand’s disease (hereditary bleeding disorder)

OTHER CAUSES OF COAGULOPATHY

There are other causes too, which affects the blood clotting ability, like chronic disease, severe infection, and the long-term use of certain medications. The conditions that may lead to coagulopathy include:

• Use of Anticoagulant drug, such as heparin.
• Disseminated intravascular coagulation (DIC).
• Idiopathic thrombocytopenic purpura (ITP).
• Long-term use of antibiotic.
• Chronic hepatic disease
• Viral infection
• Vitamin K deficiency

DIAGNOSIS OF COAGULOPATHY

Coagulopathy diagnosis undergoes different tests:

1. Complete Blood Count with Platelet- This is done to know the quantity of Red Blood Cells, White Blood Cells, and Platelet counts.
2. Bleeding Time - This is done to know the time (in seconds) the small blood vessels to close and stop the bleed.
3. Fibrinogen Level - This is done to measure the number of proteins and clotting factor (Factor 1) that plays a role in blood clotting.
4. Hageman Factor Assay, Factor 5, Factor 7, Factor 8, and Factor 10 level - This is to know the measurement of the levels of the essential clotting factors important for blood clotting process.
5. Partial Thromboplastin Time (PTT) - It is the blood test that measures the total clotting time per cycle.

RISK FACTORS FOR COAGULOPATHY

There are several factors which increase the risk of developing coagulopathy. Risk factors for coagulopathy include:

• Menorrhagea, in the case of Von Willebrand’s disease
• Male gender, in the case of hemophilia
• Parent or sibling with coagulopathy disorder

DIETARY CHANGES FOR COAGULOPATHY

Blood clotting is very essential for preventing hemorrhages when you have been cut or bruised. Some dietary changes essential for the body to carry out the process of blood clotting, and you can get these nutrients from eating a balanced diet.

Leafy Vegetables

Leafy green vegetables are the best sources of vitamin K, which is named from the German word for 'coagulation', according to the Linus Pauling. The primary function of vitamin K is as an essential component for coagulation cascade. A spinach, broccoli and parsley each provides vitamin K nutrient. Vitamin K also get from soybean oil.

Dairy Products

Dairy products help in blood clotting because of their calcium. Calcium is an essential mineral in the coagulation cascade that results in blood clotting. Milk, cheese and yogurt are rich sources of calcium.

Foods High in Manganese

Good sources of this mineral, which is important for blood clotting, healing wounds and forming strong bones, you need to the trace mineral manganese. Theses include tea, seafood, beans, nuts, seeds, whole-wheat bread, tofu and green leafy vegetables. Wild blueberries, coconut, okra also provide significant amounts of manganese as well.

Foods High in Copper

If person not taking proper copper in the diet, it could cause difficulties in blood clotting. Copper is very important for immune function and help in forming RBCs. The significant amount is found in seafood, beans, nuts, seeds, mushrooms, kale, avocado, dried fruit, goat cheese, quail and coconut.

TREATMENT OF COAGULOPATHY BY PLANET AYURVEDA

Ayurveda is known as "Science of Life". Planet Ayurveda is a herbal manufacturing company. Planet Ayurveda provides the herbal formulation such as Pitta balance, Shatavari, Moringa. These herbs specially increases the platelet count. The herbs which are used to treat coagulopathy, are 100% natural and have no side effect.

Herbal Remedies for Coagulopathy

1. Pitta Balance

According to Ayurveda our body is made up of 5 elements – Earth, water, fire, space and 3 physiological humors – vatta, pitta, kapha which represent 5 elements. Pitta balance capsules from planet Ayurveda is a great product which helps to balance pitta dosha in our body which is a root cause of infections and disorders. Pitta represents the fire. This medicine has cooling effects on the body.

The ingredients of Pitta balance are praval pishit, akik pishti, Jahar mohra pishti, kamdudha ras, mukta pishti and giloy satva.

Dosage: 1 to 2 Capsule twice daily with plain water after meal.

2. Shatavari Capsules

These capsules are prepared from the extracts of the ‘Shatavari’ herb (Asparagus racemosus) which has the ability to enhance the overall strength of the body. The herb is known for its excellent antioxidant properties, and it can nourish the tissues of the body.

The use of Shatavari capsules can be beneficial for managing blood clotting ability because these capsules can support the healthy immune system, increases the blood clotting factors, cure fatigue and general weakness, promote healthy energy levels, and treat anaemia.

Dosage: 1-2 capsules with plain water, two times a day, after meals.

3. Moringa Capsules

This herb is commonly known as Shigru or Drumstick or horse-raddish tree. It balances vata and kapha doshas. Moringa has anti-oxidant properties. It also prevents our body from various infections. Seed powder of Moringa oleifera is used in coagulopathy.

Dosage: 1-2 Capsules once or twice daily with plain water.

Contact my assistant to provide you the costing / ordering and delivery information at - costing.planetayurveda@gmail.com or call at +91-172-5214030