Treatment of Afibrinogenemia in Ayurveda with Herbal Remedies

Abstract

It is a genetically inherited blood fibrinogen disorder in which the blood does not clot normally due to a lack of fibrinogen. Fibrinogen is a blood protein that is necessary for coagulation. It is transmitted in an autosomal recessive manner. The hemorrhagic conditions sometimes can be life-threatening. It occurs in approximately 1 in 1 million people. Abolghasemi and Shahverdi (2015) mention that there have been about 250 cases is reported in the world literature.

We have discussed important points like Ayurvedic aspects, symptoms, causes, risk factors, the complication with some effective home and herbal remedies.

Introduction of Afibrinogenemia

Afibrinogenemia is also known as congenital afibrinogenemia. Afibrogenemia is a rare bleeding disorder in which the absence of fibrinogen in the blood that is a protein that is essential for blood clotting. People suffering from this disease may have severe bleeding episodes, specifically during infancy or childhood. Bleeding may occur anywhere in the body including nose, skin, gastrointestinal tract, joints, liver, muscles, genitals, and urinary tract. This disorder is an autosomal recessive that means two unaffected parents can have a child with this disorder.

The lack of fibrinogen can be seen with excessive and sometimes uncontrollable bleeding. Diagnosis can often be made at the time of birth because affected infants have severe bleeding in the umbilical cord. Early diagnosis of congenital afibrinogenemia will help in the treatment and also helps in preventing an individual from having severe bleeding or particularly bleeding inside the skull which can lead to death.

Ayurvedic aspect for Afibrinogenemia

Ayurveda is a traditional and ancient form of medicine. It is a holistic approach to health. The goal of Ayurveda is to maintain a healthy person's health and to alleviate disorders of the diseased. Ayurveda believes in maintaining health by balancing the mind, body, and soul. This balance can be maintained by the balance between Dosha, Dhatu, and Mala. Dosha is of three types each having its dominating factors like Vata has Air dominating factor, Pitta has Fire dominating factors and Kapha has water dominating factors. The balance between these Dosha is known as a healthy state of body and imbalance of these Dosha can cause various health problems.

According to Ayurveda, afibrinogenemia is a type of Sehajvikar (congenital) due to deficiency of the components of Raktadhatu which interfere with Raktastambhak action of Raktadhatu. People with this disease can have a higher risk of hemorrhage (severe bleeding) specifically in babies or young children. Newborns may have excessive bleeding from the umbilical cord. Pancha Mahadhutas plays an important role in the growth of a fertilized ovum and the formation and development of fetus organs.

Symptoms of Afibrinogenemia

• Gastrointestinal bleeding
• Nosebleed
• Gum bleeding
• Bleeding into the space of joints
• Easily bruising
• Prolonged menstrual periods
• Bleeding in the mucous membrane
• Very rare bleeding inside the skull
• Repeated miscarriages during pregnancy
• Excessive bleeding from the minor injury
• Central nervous system hemorrhaging
• Spontaneous rupture of the spleen

Causes of Afibrinogenemia

1. Mutation

Each of these genes provides instruction for making one part of a protein called fibrinogen. This protein plays an important role in clotting blood. The absence of fibrinogen in the blood is caused by a mutation in one of three genes which are known as fibrinogen alpha chain FGA, beta-chain FGB, and gamma-chain FGG genes. Mutation in FGA, FGB, and FGG can affect blood levels of fibrinogen in several ways.

2. Hereditary

Congenital afibrinogenemia is caused by a complete absence of fibrinogen protein. If the child inherits only one copy of the mutated gene, he/she becomes a carrier, and will not develop afibrinogenemia. In such cases, they will only have half of the normal levels of fibrinogen. Milder disease forms as seen if the child inherits only one gene from the parent. These patients may have abnormal bleeding only during major trauma or high-risk surgical procedures.

3. Autosomal recessive

Autosomal recessive conditions are disorders that occur when two copies of an abnormal gene have been inherited on a non-sex chromosome. If both parents have an autosomal recessive condition, there is a 100% chance of passing on the mutated genes to their children. If however, only one mutant copy of the gene is inherited, the individual will carrier of the condition, but will not be present with any symptoms. Children, born to two carriers, have a 25% chance of being homozygous dominant (unaffected), a 50% chance of being heterozygous (carrier), and a 25% chance of being homozygous recessive (affected).

Risk Factors of Afibrinogenemia

The only risk factor for this condition if both parents of a child carry the recessive linked to the disorder.

Complications of Afibrinogenemia

• A bleeding disorder is particularly disturbed the reproductive-aged women.
• Postoperative excessive bleeding.
• Bleeding disorders (digestive or urinary tract).
• Bleeding in the brain it can also lead to death.
• Heavy and prolonged menstrual bleeding can lead to serious complications.
• If afibrinogenemia women become pregnant the pre and postnatal care for women and her baby should be given.

Diagnosis of Afibrinogenemia

When a problem of fibrinogen is suspected then a test which can be performed are:

• PTT (activated partial thromboplastin time)
• Fibrinogen level in the blood
• Thrombin time
• Reptilase time
• PT (prothrombin time)

Herbal Remedies by Planet Ayurveda for Afibrinogenemia

Planet Ayurveda believes in treating people according to Ayurveda. Herbal remedies are derived from natural herbs. These herbal remedies are prepared according to the Ayurvedic principle. These herbal remedies not only provide relief from the symptoms but also work on the root cause of the disease. These herbal remedies are 100% safe and do not cause any side effects on health. These herbal remedies are free from chemicals and preservatives. For Afibrinogenemia disease Planet Ayurveda provides various herbal remedies like:

Products List

1. Kamdudha Ras Moti Yukt
2. Amalaki Rasayan
3. Amla Saar
4. Kaharva Pishti
5. Shonit Stambhak Vati
6. Giloyghan Vati

1. Kamdudha Ras Moti Yukt

Kamdudha Ras (Moti yukt)-Kamdudha ras is a blend of various herbs like Amrita satva (Tinospora cordifolia), Abhrak Bhasma (calx of mica), Praval pishti (calx of coral), Kapardika bhasma (calx of cowries), mukta bhasma (calx of pearl) etc. This will have cooling effects on the body thus helping in balancing the Pitta Dosha in the body. It also aids in health conditions like afibrinogenemia. It also assists in managing gastrointestinal bleeding, burning sensation and spontaneous rupture of spleen.

Dosage: 1 tab twice daily with plain water after meals.

2. Amalaki Rasayan

Amalaki Rasayan is a capsule preparation made using standardized extract of Amalaki (Emblica officinalis). As its name indicates that it is a rasaynik preparation which aids in balancing all the three doshas and sustains the strength to the body and supports the immune system. Amalaki rasayan also helps in anemic conditions occurring due to Gum bleeding, Bleeding into the space of joints, Easily bruising, Prolonged menstrual periods, Bleeding in the mucous membrane.

Dosage: 1 cap twice daily with plain water.

3. Amla Saar

Amla saar is a liquid syrup preparation prepared using Amla (Phyllanthus emblica). Amla is also known as Indian gooseberry and has dry and astringent properties thus helps in clotting blood. Along with pitta dosha it also helps in balancing Vata and Pitta Dosha and does detoxification of the body. This formulation is a wonderful antioxidant and removes all the endotoxins from the body.

Dosage: 2 tsp twice daily.

4. Kaharva Pishti

Kaharwa pishti is a cooling mineral preparation which prevents too much bleeding in blood dysentery, from wounds or uterine bleeding. It is made from natural extracts that have antibacterial and coagulation properties. It prevents excessive blood loss as it has astringent properties. This formulation also balances pitta dosha in the body thus manages afibrinogenemia.

Dosage: 1 tablet twice daily with plain water after meals.

5. Shonit Stambhak Vati

Shonit stambhak vati is a classical ayurvedic preparation made using ingredients like Nagkesar (Mesua ferrea), Mochrasa (Bombax malabaricum), Shuddha Laksha (Laccifer lacca) and many others. In Afibrinogenemia shonit stambhak vati helps in reducing the bleeding tendency and aids in relieving the symptoms like the Gastrointestinal bleeding, Nosebleed, Gum bleeding, Bleeding into the space of joints, Easily bruising and spontaneous rupture of spleen.

Dosage: 2 tablets twice daily with plain water after meals.

6. Giloyghan Vati

Giloy ghan vati is prepared using herb giloy (Tinospora cordifolia). Giloy is also known as Amrita as it has properties like nectar. Giloy ghan vati helps in managing the whole body functions due to its immunity boosting, antioxidant, detoxifying, anti-inflammatory, and astringent properties. Giloy helps in pacifying all the three doshas thus coping with overall weakness occurring in afibrinogenemia.

Dosage: 2 tablets twice daily with plain water after meals.

Contact my assistant to provide you the costing / ordering and delivery information at - costing.planetayurveda@gmail.com or call at +91-172-5214030

Home Remedies for Afibrinogenemia

Mothers can take this juice during pregnancy:-

1. Green Juice: Coriander, Mint, Spinach, Basil, wheatgrass, long grass juice, Sheesham leaves, green grapes add all these ingredients in a blending jar and blend it then pour the juice in a glass without straining and drink it every day.
2. Red Juice: Beetroot, Apple, Pomegranate, Marigold flower petals, Rose petals, and Black or Red grapes add all these ingredients in a blending jar and blend it then pour this juice in the glass without straining and drink it every day.

Conclusion

It is a genetically inherited blood fibrinogen disorder in which the blood does not clot normally due to a lack of fibrinogen. By using herbal remedies one can heal this disease.

Reference

https://rarediseases.info.nih.gov/diseases/5761/afibrinogenemia

Ayurvedic Treatment for Afibrinogenemia - Symptoms, Cause, Diagnosis, Risk Factors & Diet

"The absence of fibrinogen in the plasma leading to pronged bleeding"

It is a rare, genetically inherited blood fibrinogen disorder. In this disease, blood does not clot normally due to lack of fibrinogen. Fibrinogen (coagulation factor I) is a protein which is necessary for coagulation. Afibrinogenemia is an autosomal recessive trait, its meaning that two unaffected parents may have a child have this disorder. So the lack of fibrinogen results uncontrollable bleeding.

When a person who gets affected is susceptible to heavy bleeding episodes. Newborns with Afibrinogenemia usually experience heavy bleeding from the umbilical cord stump after birth. Bleeding from the gums and nose bleeding (epistaxis) are common and can occur in any age. Women with congenital Afibrinogenemia can have menorrhagia (abnormally heavy menstrual bleeding). Women with this disorder may have difficulty in a pregnancy. People affected by Afibrinogenemia experiences bleeding into the spaces between joints (hemarthrosis) or the muscles (hematoma).

SYMPTOMS OF AFIBRINOGENEMIA

There are many symptoms of Afibrinogenemia which includes:

• Nosebleed and gums bleeding
• Gastrointestinal bleeding
• Bleeding in the mucus membrane
• Bleeding into the space of joints
• Excessive bleeding from the minor injury
• Prolonged menstrual periods (menorrhagia) in women
• Repeated miscarriages during pregnancy
• Central nervous system hemorrhaging
• Easily bruising
• Very rare bleeding inside the skull (intracranial hemorrhage)

CAUSE OF AFIBRINOGENEMIA

Afibrinogenemia is due to lack of Fibrinogen (coagulation factor I). It is the protein in blood that is required in blood clotting (coagulation). Mutation in one of the fibrinogen genes alpha (FGA), beta (FGB), or gamma (FGG), alters the synthesis of fibrinogen protein. These three genes give instructions for making subunit of the fibrinogen protein. During an injury, fibrinogen is converted to fibrin. Fibrin proteins form a stable network with each unit that make up the blood clot. Mutation results in the absence of fibrin, so blood clots does not occur, leading to the excessive bleeding in the people with Afibrinogenemia.

DIAGNOSIS OF AFIBRINOGENEMIA

All the disease have a genetic component and such genetic or rare disease being diagnosed is an achievement in medical line. Doctors deeply check the medical history, symptoms, physical exam, and laboratory test results of the Patients diagnosed who are diagnosed with rare and genetic disease Diagnostic Test:

The Genetic Testing Registry (GTR) gives information about the genetic tests for this condition.

• Fibrinogen level in the blood
• Reptilase time
• Thrombin time
• PT
• Partial Thromboplastin Time (PTT) - It is the blood test that measures the total clotting time per cycle.
• Blood fibrinogen levels > 0.1 g/L and Excessive bleeding test indicates that a person having Afibrinogenemia.

RISK FACTORS FOR AFIBRINOGENEMIA

There are several factors which increase the risk of developing Afibrinogenemia. Risk factors for this disease include:

• Menorrhagia
• Male gender, in the case of hemophilia
• Parent or sibling with Afibrinogenemia disorder

DIETARY CHANGES FOR AFIBRINOGENEMIA

Blood clotting is very essential for preventing hemorrhages when you have been cut or bruised. Some dietary changes essential for the body to carry out the process of blood clotting, and you can get these nutrients from eating a balanced diet.

Vegetables

Green leafy vegetables are rich in vitamin K. The primary function of vitamin K is as an essential component for blood clotting. A spinach, broccoli, and parsley each provide vitamin K nutrient. Vitamin K also gets from soybean oil.

Dairy Products

Dairy products help in blood clotting because of their calcium. Calcium is an essential mineral in the coagulation cascade that results in blood clotting. Milk, cheese, and yogurt are rich sources of calcium.

Foods High in Manganese

Good sources of this mineral, which is important for blood clotting, healing wounds and forming strong bones, you need to the trace mineral manganese. These include tea, seafood, beans, nuts, seeds, whole-wheat bread, tofu and green leafy vegetables. Wild blueberries, coconut, okra also provide significant amounts of manganese as well.

TREATMENT OF AFIBRINOGENEMIA BY PLANET AYURVEDA

Ayurveda is known as "science of Life". Apart from modern science treatment methods, there is one another method formulated by Planet Ayurveda in which the treatment of this particular problem is done by using natural herb and herb extracts. These herbal remedies are formed with no added chemicals and there are no side effects of these herbal remedies.

Planet Ayurveda provides the herbal formulation such as Pitta balance, Spirulina, Ashwagandha. The herbs which are used to treat Afibrinogenemia.

Herbal Remedies for Afibrinogenemia

1. Pitta Balance Capsules

Pitta in our body is responsible for Metabolism, digestion, and formation of new cells. Pitta balance capsules is an herbal composition which balances the dosha in our body which disturbs the body function. This herbal composition act as a blood purifier and makes the skin healthy and clear. The herbs used in the preparation of Pitta balance are mukta pishti, praval pishit, Jahar mohra pishti akik pishti, kamdudha ras, and giloy satva.

Dosage: 1 to 2 Capsule twice daily with plain water after meal.

2. Spirulina Capsules

These capsules are prepared from the extract of the 'Arthrospira platensis herb, which has the ability to enhance the overall strength of the body. The herb is known for its excellent antioxidant properties, and it can nourish the tissues of the body.

The use of Spirulina capsules can be beneficial for managing blood clotting ability because these capsules can support the healthy immune system, increases the blood clotting factors, cure fatigue and general weakness, promote healthy energy levels, and treat anemia. Spirulina is a good source of lipid. It is a wonderful herb for good health.

Dosage: 1-2 capsules with plain water, two times a day, after meals.

3. Ashwagandha Capsules

This herb has adaptogenic & rejuvenative property as it reduces physiological & psychological stress. It helps overall well-being and prevents hair loss. It maintains a healthy immune system, calms the brain. It helps to regenerate new hairs. It has anti-anxiety property and acts as anti-stress. It contains a high concentration of withanolides which show medicinal values. This capsule work in stress, constipation, blood disorders, and has multi-effects.

Dosage: 1-2 capsules with plain water, two times a day, after meals.

Contact my assistant to provide you the costing / ordering and delivery information at - costing.planetayurveda@gmail.com or call at +91-172-5214030